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Thread: OMG! Genetically Modified Children!

  1. #1
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    Default OMG! Genetically Modified Children!

    Is cloning next?
    World's first GM babies born

    by MICHAEL HANLON, Daily Mail

    The world's first geneticallymodified humans have been created, it was revealed last night.

    The disclosure that 30 healthy babies were born after a series of experiments in the United States provoked another furious debate about ethics.

    So far, two of the babies have been tested and have been found to contain genes from three 'parents'.

    Fifteen of the children were born in the past three years as a result of one experimental programme at the Institute for Reproductive Medicine and Science of St Barnabas in New Jersey.

    The babies were born to women who had problems conceiving. Extra genes from a female donor were inserted into their eggs before they were fertilised in an attempt to enable them to conceive.

    Genetic fingerprint tests on two one-year- old children confirm that they have inherited DNA from three adults --two women and one man.

    The fact that the children have inherited the extra genes and incorporated them into their 'germline' means that they will, in turn, be able to pass them on to their own offspring.

    Altering the human germline - in effect tinkering with the very make-up of our species - is a technique shunned by the vast majority of the world's scientists.

    Geneticists fear that one day this method could be used to create new races of humans with extra, desired characteristics such as strength or high intelligence.

    Writing in the journal Human Reproduction, the researchers, led by fertility pioneer Professor Jacques Cohen, say that this 'is the first case of human germline genetic modification resulting in normal healthy children'.

    Some experts severely criticised the experiments. Lord Winston, of the Hammersmith Hospital in West London, told the BBC yesterday: 'Regarding the treat-ment of the infertile, there is no evidence that this technique is worth doing . . . I am very surprised that it was even carried out at this stage. It would certainly not be allowed in Britain.'

    John Smeaton, national director of the Society for the Protection of Unborn Children, said: 'One has tremendous sympathy for couples who suffer infertility problems. But this seems to be a further illustration of the fact that the whole process of in vitro fertilisation as a means of conceiving babies leads to babies being regarded as objects on a production line.

    'It is a further and very worrying step down the wrong road for humanity.' Professor Cohen and his colleagues diagnosed that the women were infertile because they had defects in tiny structures in their egg cells, called mitochondria.

    They took eggs from donors and, using a fine needle, sucked some of the internal material - containing 'healthy' mitochondria - and injected it into eggs from the women wanting to conceive.

    Because mitochondria contain genes, the babies resulting from the treatment have inherited DNA from both women. These genes can now be passed down the germline along the maternal line.

    A spokesman for the Human Fertilisation and Embryology Authority (HFEA), which regulates 'assisted reproduction' technology in Britain, said that it would not license the technique here because it involved altering the ggermline.

    Jacques Cohen is regarded as a brilliant but controversial scientist who has pushed the boundaries of assisted reproduction technologies.

    He developed a technique which allows infertile men to have their own children, by injecting sperm DNA straight into the egg in the lab.

    Prior to this, only infertile women were able to conceive using IVF. Last year, Professor Cohen said that his expertise would allow him to clone children --a prospect treated with horror by the mainstream scientific community.

    'It would be an afternoon's work for one of my students,' he said, adding that he had been approached by 'at least three' individuals wishing to create a cloned child, but had turned down their requests.
    I'm stunned. Isn't this illegal?
    $kipper 68 :fatal error...The more I learn,the more of danger to myself and others I've become! !

  2. #2
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    Default Re: OMG! Genetically Modified Children!

    That is interesting, we immunse against disease by ingecting modified pathogens. So how big a step is it to "immunise" against a malfunction by topping up the symbyotic mitochondria that we all need at cellular levels? Niether the father's nor mother's genes are altered in this so it is not genetic modification in the sense of GM crops.
    It really is quite difficult to build an ugly wooden boat.

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    Default Re: OMG! Genetically Modified Children!

    Genetic fingerprint tests on two one-year- old children confirm that they have inherited DNA from three adults --two women and one man.

    The fact that the children have inherited the extra genes and incorporated them into their 'germline' means that they will, in turn, be able to pass them on to their own offspring.

    Altering the human germline - in effect tinkering with the very make-up of our species - is a technique shunned by the vast majority of the world's scientists.
    "Inherited DNA from three adults --two women and one man." It's interesting they don't mention the gender of the children.
    $kipper 68 :fatal error...The more I learn,the more of danger to myself and others I've become! !

  4. #4
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    Default Re: OMG! Genetically Modified Children!

    An understanding of the difference between the mitochondrial DNA and the nucleus' DNA might be helpful :-)


    Kaa

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    Default Re: OMG! Genetically Modified Children!

    What is the difference? What could be the ramifications of this procedure on these children in the future? With both woman's genes, I'm sure this is why the pregnancy's went to term. Otherwise wouldn't the mother have miscarried them as an unknown parasite? I know I couldn't carry males, as all fetus are female until 8 weeks along, then change to male. My body rejected them. That's why this is fascinating to me.
    Last edited by skipper68; 07-16-2012 at 11:12 AM.
    $kipper 68 :fatal error...The more I learn,the more of danger to myself and others I've become! !

  6. #6
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    Default Re: OMG! Genetically Modified Children!

    Quote Originally Posted by skipper68 View Post
    What is the difference? What could be the ramifications of this procedure on these children in the future?
    The Bilge doesn't look like a good place for an introduction to human biology. Aren't you interested in how your body works? Read up on that a bit ;-)

    The immediate ramification seems to be the ability to fix certain kinds of genetic defects. That, of course, assuming that the regulators don't kill this whole line of research :-/

    Kaa

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    Default Re: OMG! Genetically Modified Children!

    Yes I plan on reading up on this. I did edit my question tho, as it has applied to me in the past.. Wouldn't the genetic defects still be inherited with the mothers original DNA??
    $kipper 68 :fatal error...The more I learn,the more of danger to myself and others I've become! !

  8. #8
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    Default Re: OMG! Genetically Modified Children!

    Quote Originally Posted by skipper68 View Post
    Yes I plan on reading up on this. I did edit my question tho, as it has applied to me in the past.. Wouldn't the genetic defects still be inherited with the mothers original DNA??
    That depends. Genetic defects in the mitochondrial DNA (mDNA) would NOT be inherited since the gist of the technique seems to be the replacement of the mother's mDNA with another person's mDNA. Genetic defects in the nuclear DNA might or might not be inherited in the normal fashion.

    Kaa

  9. #9
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    Default Re: OMG! Genetically Modified Children!

    Thanks for your answer. Do you think the children would look like the original mother, or the donated DNA 's in appearance? This is my last question.
    $kipper 68 :fatal error...The more I learn,the more of danger to myself and others I've become! !

  10. #10
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    Default Re: OMG! Genetically Modified Children!

    Why didn't they just use some of the male's mitochondria?

  11. #11
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    Default Re: OMG! Genetically Modified Children!

    Quote Originally Posted by skipper68 View Post
    Thanks for your answer. Do you think the children would look like the original mother, or the donated DNA 's in appearance? This is my last question.
    The donated DNA is mitochondrial DNA, it affects things on intracellular level, it does not affect things like appearance.

    Mitochondrial DNA is a funny thing, it's always and completely inherited from the baby's mother. A purely matrilineal line of descent. Men's mDNA is irrelevant for genetics, it's not going anywhere.

    Kaa

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    Default Re: OMG! Genetically Modified Children!

    I think it has been fairly evident now for some years, perhaps a decade, even more, that our ethical, moral, and philosophical considerations have not kept up with the rate of scientific change. This is but one example.
    Gerard>
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  13. #13
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    Default Re: OMG! Genetically Modified Children!

    I am a direct descendant of Anne Hutchinson through the female line. This is the basis for Dan Huisjen's argument that intransigence is carried in mitochondrial DNA.

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