View Full Version : Cancer Breakthrough

04-04-2013, 07:46 PM
This sounds like a huge breakthrough in cancer research.

Over ten years of cancer research paid off with the truly groundbreaking discovery of an "ultimate antibody" against cancer -- since it kills not just one or two, but all types of human cancer that it was tested on until now, it could result in a single treatment that would go a long way against the disease.

Scientists at the Stanford School of Medicine discovered a suspicous link between cancer cells and high levels of a protein called CD47 while studying leukemia a decade ago. Irving Weissman, the biologist behind the breakthrough, continued to study CD47 and found a CD47-blocking antibody that could cure some cases of leukemia by helping the immune system to recognize cancer cells as foreign and hostile cells that have to be destroyed.

The trick of the cancer cells is that the elevated amounts of CD47 produced by them function as a stealth cloak, effectively tricking the immune system into not destroying the cancer cells. Weissman discovered this by establishing a link between CD47 and most of the primary cancer types that affect humans, finding that cancer cells always had higher levels of CD47 than healthy cells.

"What we've shown is that CD47 isn't just important on leukemias and lymphomas," says Weissman, according to Science magazine. "It's on every single human primary tumor that we tested."

Weissman and his team used that observation to develop an antibody that blocks cancer cells' CD47, causing the body's immune system to attack the cancerous cells.

In tests on laboratory mice infected with a litany human cancers -- breast, ovarian, colon, bladder, brain, liver prostate -- the antibody was demonstrated to trigger the mice's immune systems to kill the tumorous cells.

"We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis," said Weissman.

The next step is a period of clinical tests in humans, which can be initiated now thanks to a $20 million grant by the California Institute for Regenerative Medicine to move the findings to human safety tests.

"We have enough data already that I can say I'm confident that this will move to phase I human trials," said


04-04-2013, 07:50 PM
Would be awesome if it truly works out.



04-04-2013, 07:55 PM
Now that would be amazing!

04-04-2013, 07:57 PM
Fingers crossed

04-04-2013, 09:10 PM
Here is another source for this story.


M. J. Notigan
04-04-2013, 09:17 PM
Encouraging news! Thank you for posting.

Take Care,

04-04-2013, 09:30 PM
I see these new strategies quite frequently but when I bring them up with my Onc he always says, yes, that will be something to hope for...sometime in the next ten years or so.

I'm OK with that.

04-05-2013, 02:34 AM
Not if you get cancer in 5 years.

Still, sounds like a plan. I hope the human trials pan out.

04-05-2013, 02:49 AM
In 2003 - 2004 Dave's oncologist predicted a couple of things that are already in the pipeline. Every day counts for thousands of folks out there.


04-05-2013, 05:23 AM
I will lose my Dad to cancer somewhere in the next few days. I told him today to hang on until next Wednesday- his birthday. I told him that 87 sounds way better than 86. He said sorry mate but I'm not gonna make it. He's the best man I've ever known and the best friend I've ever had. Seeing him so weak and in pain and not being able to help in any way is almost unbearable. He is still living on the farm- alone- with no electricity or running water. He smiles and says he likes being independent. As with everything else he has ever dealt with, he's facing death with courage, dignity and humour. And if there was a cure for cancer I might have been able to enjoy his company and counsel for a few more years. Cancer in different forms has claimed my mother, both grandfathers, several uncles and aunts, two cousins, several neighbours and numerous friends and aquaintances. And the various medical institutions still have to resort to public appeals for donations to fund their research- something which has angered me for years. If money can cure cancer then our governments should provide all funds necessary until cures are found. They always seem able to find a few more billion to fund a good war. JayInOz

04-05-2013, 05:46 AM
Much sympathy with your situation, but at least you have had time to talk and come to terms with a sad situation.
For yourself your family history means that you have to keep a very close watch on your own body now.

04-05-2013, 07:01 AM
A ray of hope.